Recombinant Human CD147/Basigin Protein

SKU: PKSH031783

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation:

Target Synonym: 5F7;BSG;Basigin;CD147;Collagenase Stimulatory Factor;EMMPRIN;Extracellular Matrix Metalloproteinase Inducer;Leukocyte Activation Antigen M6;OK Blood Group Antigen;TCSF;Tumor Cell-Derived Collagenase Stimulatory Factor

Research Areas: Cardiovascular;Neuroscience;Cancer;immunology;metabolism

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: None

UNIProt ID: P35613

Accession: NP_940991.1

Background: CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer); also known as Basigin (BSG); is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis; embryo implantation; neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells; and thereby promotes invasion; metastasis; growth and survival of malignant cells. Furthermore; CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently; CD147 displays increased expression in many cancers; and it has been previously demonstrated to participate in cancer metastasis and progression. Thus; CD147 and its antibody are used as an effective treatment for malignant cancers.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-His 205

Purity: > 97 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 20.7 kDa

ObservedMW: 35-38 kDa