Recombinant Human BMP-2 protein

SKU: CD02241

Size:2 ug

Background:Bone Morphogenetic Protein 2 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-2 is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. It is a potent osteoinductive cytokine and plays its role in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. As it shown to stimulate the production of bone, the recombinant human BMP-2 is available for orthopaedic usage and dentisty. The functional form of BMP-2 is a disulflde-linked homodimer and about 26 kDa The precursor of BMP-2 is 259 a.a., containing the 23 a.a. N-terminal signal sequence which will be cleaved by a furin-type protease to form the mature peptide.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Bone Morphogenetic Protein 2

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by inducing alkaline phosphatase production of Mouse ATDC5 cells is less than 2 ng/ml, corresponding to a specific activity of > 5. × 13 IU/mg.

Synonyms:BMP-2,BDA2A, SSFSC, SSFSC1, BMP2, Human

Endotoxin:Less than 1 EU/μg of rHuBMP-2 as determined by LAL method.

Storage:-20ºC

Sequence:MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR

uniprot accession:P12643

Molecular weight:Approximately 26. kDa, a homodimeric protein consisting of two 115 amino acid non-glycosylated polypeptide chains.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution containing 1 mM sodium citrate pH 3.5.