Recombinant Human ACVRL1 Protein(His Tag)

SKU: PDMH100250

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:ACVRL1

Target Synonym:Activin A receptor;Activin A receptor type II like 1;Activin A receptor;type II like kinase 1;Activin receptor like kinase 1;Activin receptor-like kinase 1;ACVL1;ACVRL1;ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;Osler Rendu Weber syndrome 2;Serine/threonine protein kinase receptor R3;Serine/threonine-protein kinase receptor R3;SKR3;TGF B superfamily receptor type I;TGF-B superfamily receptor type I;TSR-I;TSR1

Research Areas:Cancer;Cardiovascular;Metabolism;Signal Transduction

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:P37023

Accession:P37023

Background:This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with an other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine-and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with an other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with an hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Concentration:

Activity:Not validated for activity

Sequence:Asp22-Gln118

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:10.5 kDa

ObservedMW:25-30 kDa