Recombinant Human ACSL4 Protein(Sumo Tag)

SKU: PDEH100661

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:ACSL4

Target Synonym:ACS;ACSL;FACL;LACS;MRX;ACSL4;ACS4;FACL4;LACS4;MRX63;MRX68;ACS 4;ACSL 4;acyl CoA synthetase 4;Acyl CoA synthetase long chain family member 4;FACL 4;Fatty acid Coenzyme A ligase;fatty acid Coenzyme A ligase long-chain 4;LACS 4;Lignoceroyl CoA synthase;Long chain 4;long chain acyl CoA synthetase 4;long chain fatty acid CoA ligase 4;long chain fatty acid Coenzyme A ligase 4;Long-chain acyl-CoA synthetase 4;Long-chain-fatty-acid--CoA ligase 4

Research Areas:Signal Transduction

Conjugation:

Target Species:Human

Expression Host:E.coli

Application:

Fusion tag:N-Sumo

UNIProt ID:O60488

Accession:O60488

Background:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis.

Concentration:

Activity:Not validated for activity

Sequence:Leu184-Tyr277

Purity:> 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Endotoxin:< 10 EU/mg of the protein as determined by the LAL method

Calculated MW:26.3 kDa

ObservedMW:30 kDa