Recombinant HER4/ErbB4 Monoclonal Antibody

SKU: AN301872L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:HER4/ErbB4

Target Synonym:ALS;HER;ERBB;Proto-oncogene-like protein c-ErbB;Receptor tyrosine-protein kinase erbB;Tyrosine kinase-type cell surface receptor HER;p180erbB;HER4/ErbB;ALS19;HER4;p180erbB4;ERBB4;HER4/ErbB4;Proto-oncogene-like protein c-ErbB-4;Receptor tyrosine-protein kinase erbB-4;Tyrosine kinase-type cell surface receptor HER4;4ICD;Avian erythroblastic leukemia viral oncogene homolog 4;Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4;E4ICD;EC 2.7.10.1;ERBB4 intracellular domain;HER 4;human epidermal growth factor receptor 4;Mer4;MGC138404;Oncogene ERBB4;Receptor protein tyrosine kinase erbB 4 precursor;Receptor tyrosine protein kinase erbB 4;s80HER4;Tyrosine kinase type cell surface receptor HER4;v erb a avian erythroblastic leukemia viral oncogene homolog like 4;v erb a erythroblastic leukemia viral oncogene homolog 4;Verba avian erythroblastic leukemia viral oncogene homolog like 4;Verba erythroblastic leukemia viral oncogene homolog 4;v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian);VERBB2;V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4

Research Areas:Tags & Cell Markers;Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A584

UNIProt ID:Q15303

Accession:

Background:HER4/ErbB4, like other receptor tyrosine kinase family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain. By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling. ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in research studies suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Concentration:1 mg/mL

Immunogen:Recombinant human HER4/ErbB4 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:IHC 1:200-1:1000;IF 1:50

Calculated MW:

ObservedMW: