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Updated Date: Stock Protein updated on 20170405
Research areas: Microbiology
Target / Protein: vacA
Biologically active: Not Tested
Expression system: E.coli
Species of origin: Helicobacter pylori (Campylobacter pylori)
Delivery time: 3-7 business days
Uniprot ID: Q48253
AA Sequence: KYEKPTNVWANAIGGTSLNNGSNASLYGTSAGVDAYLNGEVEAIVGGFGSYGYSSFSNQANSLNSGANNTNFGVYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLQDLNQSYHYLAYSATTRASYGYDFAFFRNALVLKPSVGVSYNHLGSTNFKSNSNQVALSNGSSSQHLFNANANVEARYYYGDTSYFYMNAGVLQEFARFGSNNAVSLNTFKVNATRNPLNTHARVMMGGELQLAKEVFLNLGVVYLHNLISNASHFASNLGMRYSF
Tag info: N-terminal 6xHis-SUMO-tagged
Expression Region: 1038-1310aa
Protein length: Partial
MW: 45.7 kDa
Alternative Name(s): Cleaved into the following 2 chains: Vacuolating cytotoxin Vacuolating cytotoxin translocator
Relevance: Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions.
Reference: "Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration."Atherton J.C., Cao P., Peek R.M. Jr., Tummuru M.K., Blaser M.J., Cover T.L.J. Biol. Chem. 270:17771-17777(1995)
Purity: Greater than 90% as determined by SDS-PAGE.
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.