Recombinant GRK2 Monoclonal Antibody

SKU: AN301541L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:GRK2

Target Synonym:GRK;Adrenergic beta receptor kinase;Beta adrenergic receptor kinase;Beta-adrenergic receptor kinase;G protein coupled receptor kinase;G-protein coupled receptor kinase;ARBK;ADRBK;GRK2;ADRBK1;BARK1;BETA-ARK1;Adrenergic beta receptor kinase 1;ARBK1;Beta adrenergic receptor kinase 1;Beta ARK 1;Beta ARK1;Beta-adrenergic receptor kinase 1;Beta-ARK-1;FLJ16718;G protein coupled receptor kinase 2;G-protein coupled receptor kinase 2;BARK

Research Areas:Neuroscience;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A240

UNIProt ID:P25098

Accession:

Background:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light.

Concentration:1 mg/mL

Immunogen:Recombinant human GRK2 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:5000;IF 1:50

Calculated MW:80 kDa

ObservedMW:80 kDa