Recombinant Glutathione Peroxidase 4 Monoclonal Antibody

SKU: AN301875L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Glutathione Peroxidase 4

Target Synonym:glutathione peroxidase;GSHPx;GPx;GPX4;GPx-4;GSHPx-4;MCSP;PHGPx;SMDS;snGPx;snPHGPx;glutathione peroxidase 4;glutathione peroxidase 4;GPx-4;GSHPx-4;MCSP;PHGPx;SMDS;snGPx;snPHGPx

Research Areas:Signal Transduction;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A587

UNIProt ID:P36969

Accession:

Background:The selenoprotein glutathione peroxidase 4 (GPX4) is a master regulator of ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation. GPX4 converts lipid hydroperoxides to non-toxic lipid alcohols, therefore preventing ferroptosis. Research studies show that selenium enhances GPX4 expression and inhibits ferroptotic death to protect neurons. In addition, some therapy-resistant cancer cells depend on GPX4 to survive. Loss of GPX4 leads to ferroptosis and thus prevents tumor relapse in mice. Furthermore, redox homeostasis mediated by GPX4 is essential for activation of the cytosolic DNA-sensing cGAS-STING pathway and initiation of the subsequent innate immune response.

Concentration:1 mg/mL

Immunogen:Recombinant human Glutathione Peroxidase 4 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000

Calculated MW:22 kDa

ObservedMW:22 kDa