Recombinant Glucocorticoid Receptor Monoclonal Antibody

SKU: AN301002L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Glucocorticoid Receptor

Target Synonym:NR3C;nuclear receptor subfamily;glucocorticoid nuclear receptor variant;Nuclear receptor subfamily 3 group C member;GCCR;GCR;GCRST;GR;GRL;NR3C1;glucocorticoid nuclear receptor variant 1;Glucocorticoid receptor;Grl1;group C;member 1 (glucocorticoid receptor);nuclear receptor subfamily 3;Nuclear receptor subfamily 3 group C member 1

Research Areas:Epigenetics and Nuclear Signaling;Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:12B8

UNIProt ID:P04150

Accession:

Background:This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Glucocorticoid Receptor protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:1000-1:4000;WB 1:1000-1:5000

Calculated MW:85 kDa

ObservedMW:94 kDa