Recombinant FOXL2 Monoclonal Antibody

SKU: AN301526L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:FOXL2

Target Synonym:FOXL;Pfrk;Foxl2

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A225

UNIProt ID:O88470

Accession:

Background:Winged helix forkhead transcription factor 2 (FOXL2) promotes the proliferation and differentiation of granulosa cells by regulating the transcription of target genes, which is a key factor for ovarian differentiation and function maintenance. FOXL2 repels SOX9, Sertoli cells inhibit the transcription of SOX9 gene to prevent the transdifferentiation of the ovary to the testis; FOXL2 can also participate in the physiological regulation of endometrial tissue. Mutation of FOXL2 can cause small eyelid syndrome (BPES) and premature ovarian failure, so FOXL2 can be used as an important indicator of the prognosis and tumor progression of ovarian granulosa cell tumor, and it is also a specific marker of ovarian sex cord stromal tumor (SCST)

Concentration:1 mg/mL

Immunogen:Recombinant human FOXL2 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000;IHC 1:100-1:1000

Calculated MW:38 kDa

ObservedMW:50 kDa