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GeneBio Systems

Recombinant DR5 Monoclonal Antibody

Recombinant DR5 Monoclonal Antibody

AN301856L

£302.00 GBP
£302.00 GBP
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Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:DR5

Target Synonym:UNQ;PRO;Death Receptor;TRAIL Receptor;TNF-Related Apoptosis-Inducing Ligand Receptor;TRICK;ZTNFR;TRAILR;TRAIL-R;KILLER/DR;CD262;DR5;KILLER;KILLER/DR5;TRAIL-R2;TRAILR2;TRICK2;TRICK2A;TRICK2B;TRICKB;ZTNFR9;TNFRSF10B;Death Receptor 5;TNF-Related Apoptosis-Inducing Ligand Receptor 2;TRAIL Receptor 2;Tumor Necrosis Factor Receptor Superfamily Member 10B;UNQ160;PRO186;DR5;KILLER;TNFRSF10b

Research Areas:Cell Biology;Signal Transduction;Cancer;Cardiovascular

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A568

UNIProt ID:O14763

Accession:

Background:DR5, also known as CD262, TNFRSF10B, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF). It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells. DR5 contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which DR5 is capable to transmit the apoptotic signal. In PDAC cells, especially Panc89 cells, it expresses additionally to the approximately 48 and 40 kDa forms of DR5, a faster migrating variant of DR5 of about 32 kDa. The TRAIL receptor 2 (death receptor 5, or DR5) forms receptor dimers in a ligand-dependent manner.

Concentration:1 mg/mL

Immunogen:Recombinant human DR5 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:5000;IHC 1:200-1:1000

Calculated MW:48 kDa

ObservedMW:40,48 kDa

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