Recombinant Doublecortin Monoclonal Antibody

SKU: AN301300L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Doublecortin

Target Synonym:DBCN;DC;LISX;SCLH;XLIS;DCX;Dbct;Doublecortex;doublecortin;Doublin;FLJ51296;Lis X;Lissencephalin X;Lissencephalin-X;Lissencephaly X linked;Lissencephaly X linked doublecortin;Lis-X;Neuronal migration protein doublecortin;OTTHUMP00000023859;OTTHUMP00000023860;OTTHUMP00000216315;OTTHUMP00000216316

Research Areas:Neuroscience;Tags & Cell Markers

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:6C3

UNIProt ID:O43602

Accession:

Background:This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Doublecortin protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:41 kDa

ObservedMW:41 kDa