Recombinant Cynomolgus macaques ABL1 protein (His tag)

SKU: PDEC100007

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:ABL1

Target Synonym:ABL 1;Abelson tyrosine protein kinase 1;JTK7;Proto-oncogene c-Abl;bcr/abl;p150;v abl

Research Areas:Signal Transduction;Cancer;Epigenetics and Nuclear Signaling;Neuroscience

Conjugation:

Target Species:Cynomolgus macaques

Expression Host:E.coli

Application:

Fusion tag:N-His

UNIProt ID:A0A2K5X6F2

Accession:A0A2K5X6F2

Background:Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Concentration:

Activity:Not validated for activity

Sequence:Met 1-Phe 264

Purity: > 95% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 10 EU/mg of the protein as determined by the LAL method.

Calculated MW:28.9 kDa

ObservedMW:35 kDa