Recombinant COPS3 Monoclonal Antibody

SKU: AN301497L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:COPS3

Target Synonym:SGN;Csn;COPS;COPS3;CSN3;SGN3;Constitutive photomorphogenic homolog subunit 3;COP 9 (constitutive photomorphogenic) subunit 3;COP 9 complex homolog subunit 3;COP 9 complex S3;COP 9 complex subunit 3;COP 9 constitutive photomorphogenic homolog subunit 3;COP 9 homolog;COP 9 signalosome complex subunit 3;COP 9 signalosome subunit 3;COP 9 subunit 3;COP9 (constitutive photomorphogenic) subunit 3;COP9 complex homolog subunit 3;COP9 complex S3;COP9 complex subunit 3;COP9 constitutive photomorphogenic homolog subunit 3;COP9 homolog;COP9 signalosome complex subunit 3;COP9 signalosome subunit 3;COP9 subunit 3;COPS 3;CSN 3;JAB 1 containing signalosome subunit 3;JAB1 containing signalosome subunit 3;JAB1-containing signalosome subunit 3;SGN 3;Signalosome subunit 3

Research Areas:Neuroscience;Cell Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A192

UNIProt ID:Q9UNS2

Accession:

Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Concentration:1 mg/mL

Immunogen:Recombinant human COPS3 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100;IF 1:50

Calculated MW:44 kDa

ObservedMW:44 kDa