Recombinant Claudin-1 Monoclonal Antibody

SKU: AN301492L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Claudin-1

Target Synonym:UNQ;PRO;CLD;CLDN1;CLD1;ILVASC;SEMP1;claudin-1;Claudin1;CLD 1;CLDN 1;SEMP 1;Senescence associated epithelial membrane protein;Senescence associated epithelial membrane protein 1;Senescence-associated epithelial membrane protein;UNQ481;PRO944;claudin-1;CLD1;ILVASC;SEMP1

Research Areas:Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A187

UNIProt ID:O95832

Accession:

Background:Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.

Concentration:1 mg/mL

Immunogen:Recombinant human Claudin-1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IHC 1:200-1:1000;IP 1:50-1:100

Calculated MW:22 kDa

ObservedMW:18 kDa