Recombinant CEACAM6 Monoclonal Antibody

SKU: AN302030L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:CEACAM6

Target Synonym:CEACAM;CEACAM6;CD66c;CEAL;NCA;Carcinoembryonic antigen related cell adhesion molecule 6;Carcinoembryonic antigen related cell adhesion molecule 6 (non specific cross reacting antigen);Carcinoembryonic antigen-related cell adhesion molecule 6;CD 66c;CD66c antigen;CEA LIKE PROTEIN;CEACAM 6;CEAM6;MGC93832;Non specific cross reacting antigen;Non-specific crossreacting antigen;Normal cross reacting antigen;Normal cross-reacting antigen

Research Areas:Tags & Cell Markers;Immunology;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A750

UNIProt ID:P40199

Accession:

Background:Carcinoembryonic antigen (CEA)-related cell adhesion molecule 6 (CEACAM6) is a member of the CEA-related cell adhesion molecule (CEACAM) family. CEACAMs bind to themselves and other family members to carry out numerous cellular functions, including proliferation, signaling, differentiation, tumor suppression, and survival. CEACAM6 is a single-chain, glycosylphosphatidylinositol (GPI)-anchored, highly glycosylated protein that is normally expressed on epithelial cells and granulocytes. CEACAM6 mediates homophilic and heterophilic cell adhesion with other CEA-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils, and plays a role in neutrophil adhesion to cytokine-activated endothelial cells. High levels of CEACAM6 expression are also observed in several different cancers. In cancer, CEACAM6 promotes tumor progression, migration, invasion, and metastasis, and therefore is considered a target for therapeutic intervention.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000;IHC 1:200

Calculated MW:37 kDa

ObservedMW:40-100 kDa