Recombinant CD39 Monoclonal Antibody

SKU: AN301981L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:CD39

Target Synonym:SPG;Ecto-ATP diphosphohydrolase;Ectonucleoside triphosphate diphosphohydrolase;ENTPD;ENTPD1;ATPDase;CD39;NTPDase-1;SPG64;CD 39;NTPDase1;Ecto-apyrase;Ectonucleoside triphosphate diphosphohydrolase 1;NTPDase 1;Ecto-ATP diphosphohydrolase 1;Lymphoid cell activation antigen;NTPDase-1;CD39 antigen;DKFZp686D194;DKFZp686I093;Ecto apyrase;Ecto ATP diphosphohydrolase;Ecto-ATPase 1;Ecto-ATPDase 1;ENTP1;ENTPD 1;FLJ40921;FLJ40959

Research Areas:Immunology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A701

UNIProt ID:P49961

Accession:

Background:CD39,also known as ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), is a multi-pass membrane ectoenzyme that metabolizes adenosine-5'-triphosphate (ATP) to regulate purinergic signaling. Purinergic signaling by extracellular ATP and its metabolites regulate many biological processes, including vascular tone, digestion, neuronal function, and inflammation in both normal and diseased states. CD39 is expressed in endothelial cells in the vasculature to regulate local platelet purinergic signaling via metabolism of ATP to adenosine. Accordingly, CD39 regulates platelet activation aggregation and contributes to the antithrombotic properties of endothelial cells. ATP and its metabolites also finely modulate the activity of T cells and macrophages. Immunomodulation is regulated, in part, by the availability of extracellular ATP and adenosine, suggesting that CD39 may play an immunosuppressive role in the tumor microenvironment.

Concentration:1 mg/mL

Immunogen:Recombinant fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:2000

Calculated MW:58 kDa

ObservedMW:78 kDa