Recombinant cAMP Protein Kinase Catalytic Subunit Monoclonal Antibody

SKU: E-AB-81539

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:Recombinant cAMP Protein Kinase Catalytic Subunit

Target Synonym:cAMP dependent protein kinase alpha catalytic subunit;cAMP dependent protein kinase beta catalytic subunit;cAMP dependent protein kinase catalytic beta subunit isoform 4ab;cAMP dependent protein kinase catalytic subunit alpha;cAMP dependent protein kinase catalytic subunit alpha;isoform 1;cAMP dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha;KAPCA;PKA C alpha;PKA C beta;PKA C-alpha;PKACA;PKACB;PPNAD4;PRKACA;PRKACAA;PRKACB;Protein kinase A catalytic subunit alpha;Protein kinase A catalytic subunit;Protein kinase A catalytic subunit beta;Protein kinase cAMP dependent catalytic alpha;Protein kinase cAMP dependent catalytic beta

Research Areas:Cancer;Metabolism;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC-P;IF;IP

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:R07-8H3

UNIProt ID:P17612

Accession:

Background:This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Concentration:300 μg/mL

Immunogen:A synthetic peptide of human cAMP Protein Kinase Catalytic subunit

Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Purification method:Affinity Purified

Dilution:WB 1:1000-1:2000;IHC 1:50-1:100;IF 1:50-1:100

Calculated MW:41kDa

ObservedMW:41kDa