Recombinant Calreticulin Monoclonal Antibody

SKU: AN301032L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Calreticulin

Target Synonym:CRP;ERp;endoplasmic reticulum resident protein;CaBP;CALR;CRT;HEL-S-99n;RO;SSA;cC1qR;CaBP3;calregulin;Calreticulin;calsequestrin-like protein;CRP55;endoplasmic reticulum resident protein 60;ERp60;CRTC;Autoantigen RO;CALR protein;calreticulin);Epididymis secretory sperm binding protein Li 99n;FLJ26680;grp60;HACBP;HEL S 99n;Sicca syndrome antigen A;Sicca syndrome antigen A (autoantigen Ro;Calregulin

Research Areas:Tags & Cell Markers;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5A7

UNIProt ID:P27797

Accession:

Background:Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Calreticulin protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:1000-1:5000

Calculated MW:48 kDa

ObservedMW:55 kDa