Recombinant c-Myc Monoclonal Antibody

SKU: AN301056L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:c-Myc

Target Synonym:bHLHe;MYC BHLHE;MRTL;MYCC;bHLHe39;c-Myc;MYC;MYC BHLHE39;AU016757;Avian myelocytomatosis viral oncogene homolog;c Myc;Class E basic helix-loop-helix protein 39;Myc protein;Myc proto oncogene protein;Myc proto-oncogene protein;Myc2;myc-related translation/localization regulatory factor;Myelocytomatosis oncogene;Niard;Nird;Oncogene Myc;OTTHUMP00000158589;Proto-oncogene c-Myc;Protooncogene homologous to myelocytomatosis virus;RNCMYC;Transcription factor p64;Transcriptional regulator Myc-A;V-Myc avian myelocytomatosis viral oncogene homolog;v-myc myelocytomatosis viral oncogene homolog (avian);V-myc myelocytomatosis viral oncogene homolog(avian)

Research Areas:Epigenetics and Nuclear Signaling;Stem Cells;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:8D4

UNIProt ID:P01106

Accession:

Background:MYC(v-myc avian myelocytomatosis viral oncogene homolog) Homo sapiens The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human c-Myc protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1000;WB 1:1000-5000

Calculated MW:48 kDa

ObservedMW:60 kDa