Recombinant Bcl-XL Monoclonal Antibody

SKU: AN301019L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Bcl-XL

Target Synonym:Bcl-2-Like Protein;PPP1R;Bcl2-L;BCL2 like;BCL2L1;BCL-XL/S;BCL2L;BCLX;Bcl-X;PPP1R52;BCL2 like 1;Bcl-XL;Apoptosis Regulator Bcl-X;Bcl2-L-1;Bcl-2-Like Protein 1;BCLXL;BCLXS;bcl-xS;Apoptosis regulator Bcl X;Apoptosis regulator BclX;B cell lymphoma 2 like;B2CL1;Bcl 2 like 1 protein;Bcl X;Bcl xL;BCL XL/S;Bcl xS;Bcl2 related gene;DKFZp781P2092;Protein phosphatase 1 regulatory subunit 52;Bcl-x

Research Areas:Cell Biology;Signal Transduction;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:3P6

UNIProt ID:Q07817

Accession:

Background:The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Bcl-XL protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:1000-1:5000

Calculated MW:26 kDa

ObservedMW:30 kDa