Recombinant Aurora B Monoclonal Antibody

SKU: AN301441L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Aurora B

Target Synonym:IPL;ARK;AIK;AIRK;PPP1R;STK;AIM;AIK2;AIM-1;AIM1;ARK2;AurB;IPL1;PPP1R48;STK12;STK5;aurkb-sv1;aurkb-sv2;AURKB;Aurora B;AIRK2;STK1

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A136

UNIProt ID:Q96GD4

Accession:

Background:Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis.

Concentration:1 mg/mL

Immunogen:Recombinant human Aurora B fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100;IF 1:50

Calculated MW:39 kDa

ObservedMW:39 kDa