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GeneBio Systems

Recombinant ATG9A Monoclonal Antibody

Recombinant ATG9A Monoclonal Antibody

AN301795L

£302.00 GBP
£302.00 GBP
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Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:ATG9A

Target Synonym:MGD;mATG;APG9L;ATG9A;APG9L1;MGD3208;mATG9;APG9 autophagy 9-like 1;APG9 like 1;APG9-like 1;ATG9;ATG9 autophagy related 9 homolog A;ATG9 autophagy related 9 homolog A (S. cerevisiae);Autophagy 9-like 1 protein;Autophagy related 9A;Autophagy related protein 9A;Autophagy-related protein 9A;OTTHUMP00000206046;OTTHUMP00000206048;OTTHUMP00000206049;OTTHUMP00000206062

Research Areas:Cell Biology;Neuroscience;Cancer;Cardiovascular;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC;IF;FCM

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A507

UNIProt ID:Q7Z3C6

Accession:

Background:ATG9A are lipid scramblases that play a role in autophagosome expansion. ATG9A is present in numerous intracellular compartments, including the trans-Golgi network and early and recycling endosomes, and traffics through the secretory pathway to the plasma membrane and to the endocytic pathway from the plasma membrane. ATG9A protects cells against plasma membrane damage caused by a spectrum of exogenous and endogenous agents, including permeabilization by gasdermin and mixed lineage kinase domain like (MLKL), which generate pores at the plasma membrane or perturb plasma membrane integrity, respectively, during programmed cell death processes of pyroptosis and necroptosis. We furthermore define the ATG9A–IQGAP1 apparatus that integrates with the ESCRT system to cooperatively heal areas of plasma membrane damage.

Concentration:1 mg/mL

Immunogen:Recombinant human ATG9A fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100;IF 1:50;FCM 1:50-1:100

Calculated MW:94 kDa

ObservedMW:100 kDa

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