Recombinant ANGPTL3 Monoclonal Antibody

SKU: AN301438L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:ANGPTL3

Target Synonym:ANG;UNQ;PRO;FHBL;Angiopoietin;angiopoietin like;Angiopoietin-like protein;Angiopoietin-related protein;ANGPT;ANGPTL;ANGPTL3;ANG-5;ANGPT5;ANL3;FHBL2;angiopoietin like 3;Angiopoietin-5;Angiopoietin-like protein 3;Angiopoietin-related protein 3;ANL;UNQ153;PRO179;ANG-5;ANGPT5;ANL3;FHBL2

Research Areas:Cardiovascular;Signal Transduction;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A133

UNIProt ID:Q9Y5C1

Accession:

Background:Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol. Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT.

Concentration:1 mg/mL

Immunogen:Synthetic peptide derived from ANGPTL3 anti

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100;IF 1:50

Calculated MW:54 kDa

ObservedMW:54 kDa