RBM4 Antibody, HRP conjugated - Cat. #: CSB-PA880118LB01HU

SKU: CSB-PA880118LB01HU

Size :50ug

Clone Number:

Aliases:dkfzp547k0918 antibody; hLark antibody; lark antibody; Lark homolog antibody; lark homologue antibody; mgc75138 antibody; RBM4 antibody; rbm4 lark antibody; RBM4_HUMAN antibody; RNA binding motif 4 antibody; RNA binding motif 4a antibody; RNA-binding motif protein 4 antibody; RNA-binding motif protein 4a antibody; RNA-binding protein 4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9BWF3

Immunogen:Recombinant Human RNA-binding protein 4 protein (121-205AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5\\\'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3\\\'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3\\\'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5\\\'-CGCGCG[GCA]-3\\\' motif in vitro.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RBM4

Research Areas:Epigenetics and Nuclear Signaling