RBFOX3 Polyclonal Antibody

SKU: E-AB-12595

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: RBFOX3

Target Synonym: FLJ56884;FLJ58356;Fox-1 homolog C;fox1 homolog C;Fox3;FOX3NeuN;hexaribonucleotide binding protein 3;HRNBP3;NEUN;neuronal nuclei;Rbfox3;RFOX3;RNA binding protein fox-1 homolog 3;RNA binding protein;fox 1 homolog (C. elegans) 3

Research Areas: Cancer;Epigenetics and Nuclear Signaling;Neuroscience;Tags and Cell Markers

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human ;Mouse

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: A6NFN3

Accession:

Background: Immunoprecipitation and mass spectrometry of the two major NeuN species at 45–50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.

Concentration: 0.1 mg/mL

Immunogen: Synthetic peptide of human RBFOX3

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: WB 1:200-1:1000;IHC 1:50-200

Calculated MW: 34kDa

ObservedMW: Refer to figures