Rat Transferrin Receptor Protein 1, TFR1 ELISA Kit

SKU: E1656Ra

Size:96 Tests-1 Kit

Background:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:TFRC

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.021ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Transferrin Receptor Protein 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99376

MASS(Da):85,876

GeneID:64678

Synonyms:CD antigen CD71;TfR;TfR1;TFRC;TR;Transferrin receptor protein 1;Trfr

Gene names:TFRC

Standard solution:24ng/ml