Rat Transcription Factor GATA-4, GATA-4 ELISA Kit

SKU: E2431Ra

Size:96 Tests-1 Kit

Background:Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:GATA4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.044ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Transcription factor GATA-4

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P46152

MASS(Da):44,597

GeneID:54254

Synonyms:DNA-binding protein GATA-GT2;gata4;GATA-binding factor 4;Transcription factor GATA-4

Gene names:Gata4

Standard solution:48ng/ml