Rat Spindle and Kinetochore Associated Protein 2,SKA2 ELISA KIT

SKU: E1579Ra

Size:96 Tests-1 Kit

Background:Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. {ECO:0000250|UniProtKB:Q8WVK7}.

Research_area:

Applications:ELISA

Target_protein:Ska2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:9.52ng/L

Detection range:20-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Spindle and Kinetochore Associated Protein 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5I0J4

MASS(Da):16517

GeneID:287598

Synonyms:Ska2 Fam33a

Gene names:Ska2

Standard solution:4000ng/L