Rat Sirutin 5,SIRT5 ELISA KIT

SKU: E2620Ra

Size:96 Tests-1 Kit

Background:NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. {ECO:0000255|HAMAP-Rule:MF_03160}.

Research_area:

Applications:ELISA

Target_protein:Sirt5

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.98ng/L

Detection range:2-600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sirutin 5

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q68FX9

MASS(Da):34098

GeneID:306840

Synonyms:Sirt5

Gene names:Sirt5

Standard solution:640ng/L