Rat Sequestosome-1,SQSTM1 ELISA KIT

SKU: E3351Ra

Size:96 Tests-1 Kit

Background:Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery (By similarity). Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:11244088, PubMed:11500922). May play a role in titin/TTN downstream signaling in muscle cells (By similarity). May regulate signaling cascades through ubiquitination (By similarity). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels (By similarity). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (By similarity). {ECO:0000250|UniProtKB:Q13501, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:11500922}.; [Isoform 1]: More potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2. {ECO:0000269|PubMed:10477520}.

Research_area:

Applications:ELISA

Target_protein:Sqstm1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.55ng/ml

Detection range:1-64ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O08623

MASS(Da):47681

GeneID:113894

Synonyms:Sqstm1 Zip

Gene names:Sqstm1

Standard solution:128ng/ml