Rat Runt-related Transcription Factor 1, RUNX1 ELISA Kit

SKU: E2243Ra

Size:96 Tests-1 Kit

Background:CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:RUNX1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:6.23ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Runt-related transcription factor 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q63046

MASS(Da):48,556

GeneID:50662

Synonyms:Acute myeloid leukemia 1 protein;Aml1;Cbfa2;CBF-alpha-2;Core-binding factor subunit alpha-2;Oncogene AML-1;PEA2-alpha;PEA2-alpha B;PEBP2-alpha;PEBP2-alpha B;Polyomavirus enhancer-binding protein 2 alpha B subunit;Runt-related transcription factor 1;RUNX1;

Gene names:Runx1

Standard solution:3200ng/L