Rat Prestin,SLC26A5 ELISA KIT

SKU: E2646Ra

Size:96 Tests-1 Kit

Background:Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity). {ECO:0000250}.

Research_area:

Applications:ELISA

Target_protein:Slc26a5

Reactivity:Rat

Assay type:Sandwich

Sensitivity:3.44ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Prestin

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9EPH0

MASS(Da):81279

GeneID:83819

Synonyms:Slc26a5 Pres

Gene names:Slc26a5

Standard solution:1600ng/L