Rat Hypoxia Inducible Factor 2 Alpha,HIF2a ELISA KIT

SKU: E1631Ra

Size:96 Tests-1 Kit

Background:Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}.

Research_area:

Applications:ELISA

Target_protein:Epas1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:66.69ng/L

Detection range:125-8000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Hypoxia Inducible Factor 2 Alpha

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9JHS1

MASS(Da):96718

GeneID:29452

Synonyms:Epas1 Hif2a

Gene names:Epas1

Standard solution:16000ng/L