Rat Histidine Decarboxylase, HDC ELISA Kit

SKU: E2009Ra

Size:96 Tests-1 Kit

Background:Histidine decarboxylase (HDC) is an enzyme responsible for catalyzing the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response. Histidine decarboxylase is the sole member of the histamine synthesis pathway, producing histamine in a one-step reaction. Histamine cannot be generated by any other known enzyme. HDC is therefore the primary source of histamine in most mammals and eukaryotes. The enzyme employs a pyridoxal 5'-phosphate (PLP) cofactor, in similarity to many amino acid decarboxylases. Eukaryotes, as well as gram-negative bacteria share a common HDC, while gram-positive bacteria employ an evolutionarily unrelated pyruvoyl-dependent HDC. In humans, histidine decarboxylase is encoded by the HDC gene.

Research_area:Others

Applications:ELISA

Target_protein:HDC

Reactivity:Rat

Assay type:Sandwich

Sensitivity:9.87ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Histidine decarboxylase

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P16453

MASS(Da):73,636

GeneID:24443

Synonyms:HDC;Histidine decarboxylase

Gene names:Hdc

Standard solution:4800ng/L