Rat Glutathione Peroxidase 4, GPX-4 ELISA Kit

SKU: E1787Ra

Size:96 Tests-1 Kit

Background:Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (PubMed:1556123, PubMed:9988735). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Specifically able to suppress the production of leukotriene and prostaglandin in response to several stimuli by reducing fatty acid hydroperoxide (PubMed:9442035, PubMed:11010961). Specifically required to prevent mitochondrial cell death by mediating reduction of cardiolipin hydroperoxide (PubMed:9988735, PubMed:10506188, PubMed:10998361). Also required for normal sperm development and male fertility (By similarity). Required for male fertility by stabilizing the condensed chromatin in sperm nuclei.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:GPx-4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.31mU/L

Detection range:0.5-300mU/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glutathione peroxidase 4

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P36970

MASS(Da):22,225

GeneID:29328

Synonyms:Glutathione peroxidase 4;gpx-4;Gshpx-4;Phgpx;Phospholipid hydroperoxide glutathione peroxidase;snGpx

Gene names:Gpx4

Standard solution:320mU/L