Rat C-Jun-amino-terminal kinase-interacting protein 3,MAPK8IP3 ELISA KIT

SKU: E3323Ra

Size:96 Tests-1 Kit

Background:The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation. {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:21076496, ECO:0000269|PubMed:21775604, ECO:0000269|PubMed:23576431, ECO:0000269|PubMed:25944905}.

Research_area:

Applications:ELISA

Target_protein:Mapk8ip3

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:E9PSK7

MASS(Da):145650

GeneID:302983

Synonyms:Mapk8ip3 Jip3

Gene names:Mapk8ip3

Standard solution:24ng/ml