Rat Beclin 1, BECN1 ELISA Kit

SKU: E0897Ra

Size:96 Tests-1 Kit

Background:Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

Research_area:Immunology

Applications:ELISA

Target_protein:BECN1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.023ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Beclin 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q91XJ1

MASS(Da):51,557

GeneID:114558

Synonyms:Beclin-1;Beclin-1-C 35 kDa;Beclin-1-C 37 kDa;BECN 1;BECN1;Coiled-coil myosin-like BCL2-interacting protein;Protein GT197

Gene names:BECN1

Standard solution:24ng/mL