R-spondin1 Monoclonal Antibody

SKU: BT-MCA4135

Size:100μL

Background:R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Research_area:Others

Target_protein:R-spondin1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:7A6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:R-spondin1

Immunogen:Purified recombinant fragment of R-spondin1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):28.9kDa

UniProt accession:Q2MKA7

Synonyms:RSPO1, CRISTIN3, FLJ40906

GeneID:284654