Purified Anti-Human CD135 Antibody[4G8]

SKU: AN004060P

Size:1mg

Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Flow Cytometry Antibodies

Abbreviation:CD135

Target Synonym:Fetal Liver Kinase;Fms-Like Tyrosine Kinase;Stem Cell Tyrosine Kinase;Receptor-Type Tyrosine-Protein Kinase FLT;FLT;FLK;STK;FLT3;CD135;FLK-2;FLK2;STK1;Fetal Liver Kinase-2;FL Cytokine Receptor;FLT-3;Fms-Like Tyrosine Kinase 3;Receptor-Type Tyrosine-Protein Kinase FLT3;Stem Cell Tyrosine Kinase 1;STK-1;Flt3/Flk2; STK-1;CD 135;CD135 antigen;Fetal liver kinase 2;Flk 2;Flt 3;FMS like tyrosine kinase 3;Fms related tyrosine kinase 3;Fms-Related Tyrosine Kinase 3;Growth factor receptor tyrosine kinase type III;Ly-72;OTTHUMP0000004234;Receptor type tyrosine protein kinase FLT3;Stk 1;Tyrosine protein kinase receptor FLT3;Tyrosine-protein kinase receptor FLT3

Research Areas:Immunology;Signal Transduction

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:FCM

Usage:

Isotype:Mouse BALB/c IgG1, κ

Clonality:Monoclonal

Clone NO.:4G8

UNIProt ID:P36888

Background:This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Concentration: ≥ 1 mg/mL

Control catalog number:

Immunogen:Recombinant Human CD135 protein

Buffer:Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Purification method:>98%, Protein A/G purified

Dilution:FCM 2 μg/mL(0.5×10⁶-1×10⁶ cells)

GeneID:2322