PUMA rabbit pAb

SKU: ES3285

Size: 100μL

Source:Rabbit

Applications:WB IF;ELISA

Reactivity:Human;Mouse;Rat

Dilution:WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):23kD

Human_gene_id:27113

Human_swiss_prot_no:Q9BXH1

Subcellular_location:Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release.

Other_name:BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis

Background:This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],