PTTG1 Antibody - Cat. #: CSB-PA443065

SKU: CSB-PA443065

Size :100ul

Clone Number:

Aliases:AW555095 antibody; C87862 antibody; Cut2 antibody; EAP 1 antibody; EAP1 antibody; ESP1 associated protein 1 antibody; Esp1-associated protein antibody; hPTTG antibody; MGC126883 antibody; MGC138276 antibody; Pds1 antibody; Pituitary tumor transforming 1 antibody; Pituitary tumor transforming protein 1 antibody; Pituitary tumor-transforming 1; isoform CRA_a antibody; Pituitary tumor-transforming 1; isoform CRA_b antibody; Pituitary tumor-transforming gene 1 antibody; Pituitary tumor-transforming gene 1 protein antibody; PTTG 1 antibody; PTTG antibody; PTTG1 antibody; PTTG1 protein antibody; PTTG1_HUMAN antibody; Pttg3 antibody; Securin antibody; Tumor transforming 1 antibody; Tumor transforming protein 1 antibody; Tumor-transforming protein 1 antibody; TUTR 1 antibody; TUTR1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95997

Immunogen:Synthesized peptide derived from internal of Human PTTG1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500

Background:Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Dominguez A., Oncogene 17:2187-2193(1998).
Kakar S.S., Cytogenet. Cell Genet. 84:211-216(1999).
Zhang X., Mol. Endocrinol. 13:156-166(1999).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PTTG1

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology