PRTFDC1 Monoclonal Antibody

SKU: AN200139P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:PRTFDC1

Target Synonym:PRTFDC;HHGP;PRTFDC1

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:12B14

UNIProt ID:Q9NRG1

Accession:

Background:PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase. PRTFDC1 has a low, barely measurable phosphoribosyltransferase activity (in vitro).

Concentration:1 mg/mL

Immunogen:Recombinant Human PRTFDC1 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;

Calculated MW:28 kDa

ObservedMW:28 kDa