PPARA Polyclonal Antibody

SKU: E-AB-70253

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:PPARA

Target Synonym:hPPAR;MGC2237;MGC2452;NR1C1;Nuclear receptor subfamily 1 group C member 1;OTTHUMP00000197740;OTTHUMP00000197741;Peroxisome proliferative activated receptor alpha;Peroxisome proliferator activated receptor alpha;Peroxisome proliferator-activated receptor alpha;PPAR;PPAR-alpha;ppara;PPARA;PPARalpha

Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P23204,P37230

Accession:

Background:Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid β-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-κB, causing inhibition of its signaling pathway or reducing the activated levels of NF-κB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.

Concentration:0.6 mg/mL

Immunogen:KLH conjugated Synthetic peptide corresponding to Mouse PPARα

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:IHC 1:200-1:500

Calculated MW:

ObservedMW: