POT1 rabbit pAb

SKU: ES3245

Size: 100μL

Source:Rabbit

Applications:WB;IHC

Reactivity:Human;Monkey

Dilution:WB 1:500-2000;IHC-p 1:50-300

Immunogen:The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):70kD

Human_gene_id:25913

Human_swiss_prot_no:Q9NUX5

Subcellular_location:Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA.

Other_name:POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein

Background:protection of telomeres 1(POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008],