Porcine Alpha-Synuclein,SNCA ELISA KIT

SKU: E0411Po

Size:96 Tests-1 Kit

Background:Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. {ECO:0000250|UniProtKB:P37840}.

Research_area:

Applications:ELISA

Target_protein:SNCA

Reactivity:Porcine

Assay type:Sandwich

Sensitivity:0.2ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Alpha-Synuclein

Species:Porcine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q3I5G7

MASS(Da):14520

GeneID:641350

Synonyms:SNCA

Gene names:SNCA

Standard solution:48ng/ml