POMC Polyclonal Antibody

SKU: AN007010L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:POMC

Target Synonym:Adrenocorticotropic hormone;Alpha melanocyte stimulating hormone;alphaMSH;Beta LPH;Beta melanocyte stimulating hormone;Corticotropin lipotropin;Corticotropin-like intermediary peptide;Gamma LPH;included;Lipotropin;Lipotropin beta;Lipotropin gamma;Melanocyte-stimulating hormone;Melanotropin;Melanotropin alpha;Melanotropin beta;Opiomelanocortin prepropeptide;Pomc1;Pomc-1;Pomc2;Pro ACTH endorphin;Pro opiomelanocortin;Proopiomelanocortin;Proopiomelanocortin preproprotein;Pro-opiomelanocortin-alpha;Tetracosactide;γ-intermedin;γ-melanocortin;γ-melanotropin;ACTH;Adrenocorticotropin;alpha-MSH;Beta-endorphin;beta-MSH;CLIP;Corticotropin;gamma-MSH;LPH;Melanotropin gamma;Met-enkephalin;MSH;NPP;POC;POMC;POMC;ACTH;CLIP;LPH;MSH;NPP;POC;Adrenocorticotropin;alpha-intermedin;alpha-melanocortin;alpha-melanotropin;b-EP;Pro-opiomelanocortin;Corticotropin-lipotropin;Gamma-MSH;Corticotropin;Alpha-MSH;Beta-LPH;Gamma-LPH;Beta-MSH;Beta-endorphin;Met-enkephalin;Melanotropin gamma;Potential peptide

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P01189

Accession:

Background:This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Concentration:1 mg/mL

Immunogen:Recombinant Human POMC protein expressed by E.coli

Buffer:PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000

Calculated MW:29 kDa

ObservedMW:12 kDa