POLR3H Antibody - Cat. #: CSB-PA136237

SKU: CSB-PA136237

Size :100ul

Clone Number:

Aliases:POLR3H antibody; KIAA1665 antibody; RPC8 antibody; DNA-directed RNA polymerase III subunit RPC8 antibody; RNA polymerase III subunit C8 antibody; DNA-directed RNA polymerase III subunit H antibody; RNA polymerase III subunit 22.9 kDa subunit antibody; RPC22.9 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y535

Immunogen:Synthesized peptide derived from internal of Human RPC8.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity.

Hu P., Mol. Cell. Biol. 22:8044-8055(2002).
Hirosawa M., DNA Res. 8:1-9(2001).
Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:POLR3H

Research Areas:Epigenetics and Nuclear Signaling