POLH Polyclonal Antibody

SKU: E-AB-18829

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: POLH

Target Synonym: DNA polymerase eta;FLJ16395;FLJ21978;Polh;POLH;polymerase DNA directed eta;RAD30;RAD30 homolog A;RAD30A;Xeroderma pigmentosum variant type protein;XP V;XPV

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q9Y253

Accession:

Background: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.

Concentration: 1.08 mg/mL

Immunogen: Fusion protein of human POLH

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:50-1:300

Calculated MW:

ObservedMW: