Plasminogen receptor rabbit pAb

SKU: ES8519

Size: 100μL

Source:Rabbit

Applications:WB;IHC

Reactivity:Human;Rat

Dilution:WB 1:500-2000;IHC-p 1:50-300

Immunogen:The antiserum was produced against synthesized peptide derived from the Internal region of human PLGRKT. AA range:1-50

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):17kD

Human_gene_id:55848

Human_swiss_prot_no:Q9HBL7

Subcellular_location:Cell membrane ; Multi-pass membrane protein . Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. .

Other_name:Plasminogen receptor (KT) (Plg-R(KT))

Background:Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.